Life-span cognitive activity, neuropathologic burden, and co

Life-span cognitive activity, neuropathologic burden, and co

ViestiKirjoittaja Psykopatologia » 09.07.2013 02:35

Article http://neurology.org/content/early/2013 ... 31829c5e8a

Life-span cognitive activity, neuropathologic burden, and cognitive aging

Robert S. Wilson, PhD, Patricia A. Boyle, PhD, Lei Yu, PhD, Lisa L. Barnes, PhD, Julie A. Schneider, MD and David A. Bennett, MD
Correspondence to Dr. Wilson: rwilson@rush.edu

Published online before print July 3, 2013, doi: 10.1212/WNL.0b013e31829c5e8a
Neurology 10.1212/WNL.0b013e31829c5e8a

A B S T R A C T

Objective:
To test the hypothesis that cognitive activity across the life span is related to late-life cognitive decline not linked to common neuropathologic disorders.

Methods:
On enrollment, older participants in a longitudinal clinical-pathologic cohort study rated late-life (i.e., current) and early-life participation in cognitively stimulating activities. After a mean of 5.8 years of annual cognitive function testing, 294 individuals had died and undergone neuropathologic examination. Chronic gross infarcts, chronic microscopic infarcts, and neocortical Lewy bodies were identified, and measures of β-amyloid burden and tau-positive tangle density in multiple brain regions were derived.

Results:
In a mixed-effects model adjusted for age at death, sex, education, gross and microscopic infarction, neocortical Lewy bodies, amyloid burden, and tangle density, more frequent late-life cognitive activity (estimate = 0.028, standard error [SE] = 0.008, p < 0.001) and early-life cognitive activity (estimate = 0.034, SE = 0.013, p = 0.008) were each associated with slower cognitive decline. The 2 measures together accounted for 14% of the residual variability in cognitive decline not related to neuropathologic burden. The early-life–activity association was attributable to cognitive activity in childhood (estimate = 0.027, SE = 0.012, p = 0.026) and middle age (estimate = 0.029, SE = 0.013, p = 0.025) but not young adulthood (estimate = −0.020, SE = 0.014, p = 0.163).

Conclusions:
More frequent cognitive activity across the life span has an association with slower late-life cognitive decline that is independent of common neuropathologic conditions, consistent with the cognitive reserve hypothesis.

Received January 9, 2013.
Accepted in final form March 14, 2013.
© 2013 American Academy of Neurology
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Psykopatologia
Ylläpitäjä
 
Viestit: 57805
Liittynyt: 12.02.2010 13:19
Paikkakunta: Helsinki

Re: Life-span cognitive activity, neuropathologic burden, an

ViestiKirjoittaja Psykopatologia » 09.07.2013 18:04

Brain Gym - aivojumppa http://fi.wikipedia.org/wiki/Brain_Gym_-aivojumppa

(- -)
Aivojumpan mukaan
Aivan kuten kodin virtapiirit voivat ylikuormittua, myös neurologiset ja fysiologiset signaalit
voivat jumittua ja sammua, jolloin normaali kehon ja aivojen välinen viestintä tukkiutuu.

Asiantuntijoiden vastaus
Ajatus kuulostaa järkevältä, mutta tällaista sattuu tosi asiassa vain esimerkiksi sydän-
tai epilepsiakohtauksen kaltaisissa terveydentilan häiriöissä.
(- -)
Avatar
Psykopatologia
Ylläpitäjä
 
Viestit: 57805
Liittynyt: 12.02.2010 13:19
Paikkakunta: Helsinki


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