Habitual intake of dietary flavonoids and risk of PD
Lähetetty: 09.04.2012 02:09Article http://www.neurology.org/content/early/ ... 601e4c70d1
Habitual intake of dietary flavonoids and risk of Parkinson disease
X. Gao, MD, PhD, A. Cassidy, PhD, M.A. Schwarzschild, MD, PhD, E.B. Rimm, ScD and A. Ascherio, MD, DrPH
+ Author Affiliations
From the Channing Laboratory (X.G., E.B.R., A.A.), Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston; Departments of Nutrition (X.G., E.B.R., A.A.) and Epidemiology (E.B.R., A.A.), Harvard University School of Public Health, Boston, MA; Department of Nutrition (A.C.), Norwich Medical School, University of East Anglia, Norwich, UK; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston.
Correspondence & reprint requests to Dr. Gao: xiang.gao@channing.harvard.edu
A B S T R A C T
Objective:
To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing Parkinson disease (PD).
Methods:
In the current analysis, we included 49,281 men in the Health Professional Follow-up Study and 80,336 women from the Nurses' Health Study. Five major sources of flavonoid-rich foods (tea, berry fruits, apples, red wine, and orange/orange juice) were also examined. Flavonoid intake was assessed using an updated food composition database and a validated food frequency questionnaire.
Results:
We identified 805 participants (438 men and 367 women) who developed PD during 20–22 years of follow-up. In men, after adjusting for multiple confounders, participants in the highest quintile of total flavonoids had a 40% lower PD risk than those in the lowest quintile (hazard ratio [HR] = 0.60; 95% confidence interval 0.43, 0.83; p trend = 0.001). No significant relationship was observed in women (p trend = 0.62) or in pooled analyses (p trend = 0.23). In the pooled analyses for the subclasses, intakes of anthocyanins and a rich dietary source, berries, were significantly associated with a lower PD risk (HR comparing 2 extreme intake quintiles were 0.76 for anthocyanins and 0.77 for berries, respectively; p trend < 0.02 for both).
Conclusions:
Our findings suggest that intake of some flavonoids may reduce PD risk, particularly in men, but a protective effect of other constituents of plant foods cannot be excluded.
Received January 28, 2011.
Accepted September 13, 2011.
Copyright © 2012 by AAN Enterprises, Inc.
__________
Tutkimus: Marjat ja hedelmät pitävät Parkinsonin taudin loitolla
8.4.2012 18:35 | 0 | Jani Kaaro http://www.hs.fi/ulkomaat/Tutkimus+Marj ... 5559514177
(- -)
Habitual intake of dietary flavonoids and risk of Parkinson disease
X. Gao, MD, PhD, A. Cassidy, PhD, M.A. Schwarzschild, MD, PhD, E.B. Rimm, ScD and A. Ascherio, MD, DrPH
+ Author Affiliations
From the Channing Laboratory (X.G., E.B.R., A.A.), Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston; Departments of Nutrition (X.G., E.B.R., A.A.) and Epidemiology (E.B.R., A.A.), Harvard University School of Public Health, Boston, MA; Department of Nutrition (A.C.), Norwich Medical School, University of East Anglia, Norwich, UK; and Department of Neurology (M.A.S.), Massachusetts General Hospital, Boston.
Correspondence & reprint requests to Dr. Gao: xiang.gao@channing.harvard.edu
A B S T R A C T
Objective:
To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing Parkinson disease (PD).
Methods:
In the current analysis, we included 49,281 men in the Health Professional Follow-up Study and 80,336 women from the Nurses' Health Study. Five major sources of flavonoid-rich foods (tea, berry fruits, apples, red wine, and orange/orange juice) were also examined. Flavonoid intake was assessed using an updated food composition database and a validated food frequency questionnaire.
Results:
We identified 805 participants (438 men and 367 women) who developed PD during 20–22 years of follow-up. In men, after adjusting for multiple confounders, participants in the highest quintile of total flavonoids had a 40% lower PD risk than those in the lowest quintile (hazard ratio [HR] = 0.60; 95% confidence interval 0.43, 0.83; p trend = 0.001). No significant relationship was observed in women (p trend = 0.62) or in pooled analyses (p trend = 0.23). In the pooled analyses for the subclasses, intakes of anthocyanins and a rich dietary source, berries, were significantly associated with a lower PD risk (HR comparing 2 extreme intake quintiles were 0.76 for anthocyanins and 0.77 for berries, respectively; p trend < 0.02 for both).
Conclusions:
Our findings suggest that intake of some flavonoids may reduce PD risk, particularly in men, but a protective effect of other constituents of plant foods cannot be excluded.
Received January 28, 2011.
Accepted September 13, 2011.
Copyright © 2012 by AAN Enterprises, Inc.
__________
Tutkimus: Marjat ja hedelmät pitävät Parkinsonin taudin loitolla
8.4.2012 18:35 | 0 | Jani Kaaro http://www.hs.fi/ulkomaat/Tutkimus+Marj ... 5559514177
(- -)